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I've made fennel seed tea or infusion quite a bit (infused 20 or 30 mins). And fenugreek tea (simmered 15 mins max). Both those have strong constituents easily released into water. They seem quite different from MT seed though.

Gail Faith Edwards talks about MT seed infusion as a way of transferring the medicinal benefits to jaundiced babies via breastmilk (which suggests that some of the constituents are water soluble). Crushing MT seed does seem a good idea.

I know what you mean about sprouts, but I think it applies to the seed when the sprout bit first comes out. I'm thinking also of the practice of soaking grains and beans (a la Nourishing Traditions) to make them more digestible.

Susun does give instructions to infuse seeds for 30 mins minimum (except fenugreek), so I am assuming that that is sufficiently short enough time to not release the sprout protection chemicals (sprouting starting after soaking a day or so?)